Tiers name what a vendor publishes, not a verdict on any product's purity or quality.
Lab-verifiable COAs: certificates that open on the testing lab's own site (the seal's ring shows what share of them do).
Third-party COAs: certificates attributed to a third-party lab, which may be hosted only on the vendor's site.
Tiers follow the Vendor Score (90+ and 80–89), which is 87% COA evidence; the numeral in each seal is that score.
Affiliate relationships never affect tiers, selection or order. How the Vendor Score works
IGF-1 LR3 (Long-R3 insulin-like growth factor-1) is an 83-amino-acid analog of human IGF-1, modified by an arginine substitution at position 3 and a 13-residue N-terminal extension that reduce its binding to IGF-binding proteins. It is a research peptide studied in laboratory and cell-culture models of growth-factor signaling, cell proliferation, and receptor biology. This index tracks research-use-only (RUO) vendor pricing for IGF-1 LR3 so researchers can compare cost across suppliers.
Evidence brief
IGF-1 LR3 (Long R3 IGF-1) is a modified insulin-like growth factor-1 analog with reduced binding to the IGF-binding proteins, used chiefly as a laboratory research reagent.
A laboratory reagent — not an approved medicine anywhere; research use only.Research use only — not medical advice.
Size, form & budget
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Your comparison
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IGF-1 LR3 · all tracked vendors · all tracked peptide listings, including out-of-stock products. Prices and stock reflect the last check. Non-comparable products do not enter market rankings. Trust scores measure published evidence, not product safety.
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COACertificate of Analysis: a lab report stating a batch's measured identity and purity.Certificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 50 of 55 tracked sources for IGF-1 LR3 publish a COA
— 38 with at least one certificate you can open at the testing lab: Iron Aminos (250 at the lab), Eternal Peptides (141 at the lab), Oros Research (96 at the lab), True Research Labs (96 at the lab), RUO.bio (91 at the lab), Nationwide Peptides (88 at the lab), NuScience Peptides (87 at the lab), Paramount Peptides (81 at the lab), Tegridy-Research (81 at the lab), MOG Labs (78 at the lab), My Oasis Labs (73 at the lab), S1 Research (68 at the lab), and 38 more — every one of them is a linked row in the table above. What a COA proves →
IGF-1 LR3 (Long R3 IGF-1) is a modified insulin-like growth factor-1 analog with reduced binding to the IGF-binding proteins, used chiefly as a laboratory research reagent.
Source-linked reference figures with the population and study context alongside each amount. Study arms are not a starting dose, titration schedule, or personal treatment plan. Label records refer to the named approved medicine, not vendor products.
Dose administered in a preclinical animal study (rat, adult male Lewis rats, volumetric muscle loss model)
28 mcg or 280 mcg
rat · adult male Lewis rats, volumetric muscle loss model · preclinical animal study · Route reported: implanted muscle void filler
Research use only — this reports what an FDA label or a peer-reviewed study published, tied to its species and study context. It is not medical advice, not a recommendation to use, and no dose here is generated by pepmg. Any dosing decision is for a qualified professional. Animal-study amounts do not establish a human dose.
Reconstitution calculator → · Converts your entered quantities; it does not select a dose or establish suitability for use.
● Peer-reviewed research · IGF-1 LR3source: PubMed
StudyanimalAmerican journal of physiology. Endocrinology and metabolism · 2025 · PMID 39679943
Insulin-like growth factor-1 (IGF-1) and insulin are important fetal anabolic hormones. Complications of pregnancy, such as placental insufficiency, can lead to fetal growth restriction (FGR) with low-circulating IGF-1 and insulin…
Studyspecies not classifiedFrontiers in physiology · 2022 · PMID 36091374
IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep increased fetal organ growth and skeletal muscle myoblast proliferation. However,…
StudyhumanApplied microbiology and biotechnology · 2023 · PMID 37261455
Insulin-like growth factor-1 (IGF-1) is a pleiotropic protein hormone and has become an attractive therapeutic target because of its multiple roles in various physiological processes, including growth, development, and metabolism. However,…
A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.
Per-mg pricing for IGF-1 LR3 varies widely because vendors differ in synthesis or recombinant expression method, stated purity, vial fill size, and lot testing rigor. Comparing normalized $/mg across suppliers helps a researcher weigh cost against documented quality rather than paying a premium for equivalent material.
▸ Reading the COA
For IGF-1 LR3, confirm identity by mass spectrometry against the expected mass of roughly 9.1 kDa for the 83-residue analog, and check that the sequence reflects the Arg3 substitution and the N-terminal extension rather than native IGF-1. Look for an HPLC purity figure (commonly >=95-98%) and scrutinize the impurity profile for truncated or misfolded species and deamidation products, since incorrect disulfide folding can yield material that fails functional or identity verification despite having the same nominal mass. A legitimate COA is lot-specific and should also state endotoxin and, ideally, residual solvent or counterion content.
▸ FAQ
How should lyophilized IGF-1 LR3 be stored as a research material?
As a research material, lyophilized IGF-1 LR3 is generally kept sealed and desiccated at -20 C or colder, protected from light and moisture, where it is typically stable for extended periods. Because it is a peptide, repeated freeze-thaw cycles and prolonged exposure to room temperature after reconstitution can degrade it, which is why many labs aliquot reconstituted material to minimize cycling. Follow the specific storage conditions listed on the vendor's COA for the exact lot.
What is a COA and what should I check for on one for IGF-1 LR3?
A Certificate of Analysis (COA) is a lot-specific document reporting the analytical testing a vendor performed on the material you are buying. For IGF-1 LR3, check that mass-spectrometry data match the expected mass for the Long-R3 analog, that HPLC purity is stated with an impurity profile, and that the lot number, quantity, and storage conditions are documented. It verifies the identity and purity of the material, not any biological outcome.
Why do per-mg prices for IGF-1 LR3 differ so much between vendors?
Differences come from production route (solid-phase synthesis versus recombinant expression), stated purity grade, the depth of analytical testing (mass spec, HPLC, endotoxin), vial fill size, and packaging or handling overhead. Larger fills often lower the effective $/mg, while more extensively characterized lots may cost more. Comparing normalized $/mg alongside each vendor's COA makes these trade-offs visible.
All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label or a peer-reviewed study has published a dose, pepmg reports it with the source named, because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.
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