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● PE-22-28TREK-1 peptide

Compound dossier · evidence, sources, and tracked market

PE-22-28

TREK-1 peptide Preclinical only 1 cited study 21 tracked vendors

PE-22-28 market at a glance

Cheapest
$3.80/mg
Median · 22 listings
$5.95/mg
Highest
$10.00/mg
Vendors
21
PE-22-28 price field, $/mg by vendor Each dot is one vendor's cheapest in-stock PE-22-28 listing: 21 vendors, from $3.80 to $10.00 per mg. The market median is $5.95 per mg across 22 in-stock listings. 7 of these vendors are in the Lab-verifiable COAs tier and 6 in the Third-party COAs tier. $4 $6 $8 $10 median $5.95 6A Labs · $4.00/mgGlacier Aminos · $4.50/mgModern Aminos · $5.40/mgSouthern Aminos · $6.40/mgSupply Kore · $7.00/mgAtomik Labz · $7.50/mgSolution Peptides · $7.50/mgWelli Labs · $10.00/mgIon Peptide · $4.90/mg · Third-party COAsElite Miami Peptides · $5.90/mg · Third-party COAsAMC-Essentials · $6.00/mg · Third-party COAsCore Peptides · $6.75/mg · Third-party COAsBiotech Peptides · $6.88/mg · Third-party COAsTegridy Research · $3.80/mg · Lab-verifiable COAsIron Aminos · $4.00/mg · Lab-verifiable COAsModern Research Peptides · $4.50/mg · Lab-verifiable COAsParamount Peptides · $5.53/mg · Lab-verifiable COAsNationwide Peptides · $5.80/mg · Lab-verifiable COAsTydes · $6.25/mg · Lab-verifiable COAsOrbitrex Peptide · $7.00/mg · Third-party COAsAlpha Omega Peptide · $7.20/mg · Lab-verifiable COAs PE-22-28 price field, $/mg by vendor Each dot is one vendor's cheapest in-stock PE-22-28 listing: 21 vendors, from $3.80 to $10.00 per mg. The market median is $5.95 per mg across 22 in-stock listings. 7 of these vendors are in the Lab-verifiable COAs tier and 6 in the Third-party COAs tier. $3.80 $10.00 median $5.95 6A Labs · $4.00/mgGlacier Aminos · $4.50/mgModern Aminos · $5.40/mgSouthern Aminos · $6.40/mgSupply Kore · $7.00/mgAtomik Labz · $7.50/mgSolution Peptides · $7.50/mgWelli Labs · $10.00/mgIon Peptide · $4.90/mg · Third-party COAsElite Miami Peptides · $5.90/mg · Third-party COAsAMC-Essentials · $6.00/mg · Third-party COAsCore Peptides · $6.75/mg · Third-party COAsBiotech Peptides · $6.88/mg · Third-party COAsTegridy Research · $3.80/mg · Lab-verifiable COAsIron Aminos · $4.00/mg · Lab-verifiable COAsModern Research Peptides · $4.50/mg · Lab-verifiable COAsParamount Peptides · $5.53/mg · Lab-verifiable COAsNationwide Peptides · $5.80/mg · Lab-verifiable COAsTydes · $6.25/mg · Lab-verifiable COAsOrbitrex Peptide · $7.00/mg · Third-party COAsAlpha Omega Peptide · $7.20/mg · Lab-verifiable COAs
Lab-verifiable COAs 7 Third-party COAs 6 Other vendors 8 linear scale · one dot per vendor, its cheapest $/mg

Highest Vendor Scores, cheapest first

The 8 highest Vendor Scores among the 13 vendors carrying PE-22-28 that score 80+, ordered by $/mg

  1. Lowest $/mg of these 8

    Tegridy Research

    Lab-verifiable COAs

    $3.80/mg — view this 10 mg listing at Tegridy Research's store (opens in a new tab) ▼ 36% below median
    10 mg · $38.00
    92

    81 of 82 COAs open at Chromate Labs / Freedom DiagnosticsRing: share of COAs openable at the lab · numeral: Vendor Score

    Vendor profile Affiliate link: pepmg may earn a commission. Affiliate status never affects ranking, price order or Vendor Scores. · code pepmg

  2. Iron Aminos

    Lab-verifiable COAs

    $4.00/mg — view this 10 mg listing at Iron Aminos' store (opens in a new tab) ▼ 33% below median
    10 mg · $39.99
    96

    253 of 253+ COAs open at Freedom Diagnostics

    Vendor profile

  3. Modern Research Peptides

    Lab-verifiable COAs

    $4.50/mg — view this 10 mg listing at Modern Research Peptides' store (opens in a new tab) ▼ 24% below median
    10 mg · $44.99
    96

    276 of 315+ COAs open at Freedom Diagnostics

    Vendor profile

  4. Paramount Peptides

    Lab-verifiable COAs

    $5.53/mg — view this 10 mg listing at Paramount Peptides' store (opens in a new tab) ▼ 7% below median
    10 mg · $55.25
    99

    81 of 84 COAs open at Janoshik

    Vendor profile

  5. Nationwide Peptides

    Lab-verifiable COAs

    $5.80/mg — view this 5 mg listing at Nationwide Peptides' store (opens in a new tab) ▼ 3% below median
    5 mg · $29.00
    94

    88 of 98 COAs open at Freedom Diagnostics

    Vendor profile Affiliate link: pepmg may earn a commission. Affiliate status never affects ranking, price order or Vendor Scores.

  6. Tydes

    Lab-verifiable COAs

    $6.25/mg — view this 8 mg listing at Tydes' store (opens in a new tab) ▲ 5% above median
    8 mg · $49.99
    96

    66 of 66 COAs open at Janoshik / TrustPointe Analytics

    Vendor profile

  7. Orbitrex Peptide

    Third-party COAs

    $7.00/mg — view this 10 mg listing at Orbitrex Peptide's store (opens in a new tab) ▲ 18% above median
    10 mg · $69.99
    85

    32 of 51 COAs open at Chromate Labs / Freedom Diagnostics

    Vendor profile

  8. Alpha Omega Peptide

    Lab-verifiable COAs

    $7.20/mg — view this 10 mg listing at Alpha Omega Peptide's store (opens in a new tab) ▲ 21% above median
    10 mg · $72.00
    90

    71 of 78 COAs open at Freedom Diagnostics

    Vendor profile

Tiers name what a vendor publishes, not a verdict on any product's purity or quality. Lab-verifiable COAs: certificates that open on the testing lab's own site (the seal's ring shows what share of them do). Third-party COAs: certificates attributed to a third-party lab, which may be hosted only on the vendor's site. Tiers follow the Vendor Score (90+ and 80–89), which is 87% COA evidence; the numeral in each seal is that score. Affiliate relationships never affect tiers, selection or order. How the Vendor Score works

A seven-amino-acid spadin analogue studied preclinically as a TREK-1 channel inhibitor.

Evidence brief

PE-22-28 is a seven-amino-acid fragment designed from degradation products of spadin and studied as an inhibitor of the TREK-1 potassium channel.

read the evidence review → inspect cited studies

Published dosing & study context → Reconstitution calculator →

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first-party prices captured

Compare by exact vialThe small sealed glass container a compound ships in. size: 8mg (6 vendors)10mg (14 vendors)

email only when a vendor actually lowers a PE-22-28 price — set a $/mg to only hear when it crosses your number · one-click stop

Select up to four offers to compare side by side. Click a column heading to sort. Click again to reverse. Scroll sideways for more columns.

Tick up to four offers to compare side by side. Use Sort by to reorder. COA counts are each vendor's own library; batch match is not assumed.

PE-22-28 · all tracked vendors · all tracked peptide listings, including out-of-stock products. Prices and stock reflect the last check. Non-comparable products do not enter market rankings. Trust scores measure published evidence, not product safety.
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Tegridy Research PE-22-28 10MGPE-22-28 Vial / standard 10 $38.00 $3.80 in stock 92/100 82 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗Affiliate link: pepmg may earn a commission. Affiliate status never affects ranking, price order or Vendor Scores.
Iron Aminos PE-22-28 10MGPE-22-28 Vial / standard 10 $39.99 $4.00 in stock 96/100 253 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗
6A Labs PE-22-28PE-22-28 Vial / standard 10 $40.00 $4.00 in stock 72/100 15 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Glacier Aminos PE-22-28 10MGPE-22-28 Vial / standard 10 $44.99 $4.50 in stock 78/100 10 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗
Modern Research Peptides PE-22-28 10MG (9.97 mg)PE-22-28 Vial / standard 10 $44.99 $4.50 in stock 96/100 315 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗
Ion Peptide PE-22-28 – 10mgPE-22-28 Vial / standard 10 $49.00 $4.90 in stock 81/100 39 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Modern Aminos PE-22-28 10MGPE-22-28 Vial / standard 10 $54.00 $5.40 in stock 76/100 106 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Paramount Peptides PE-22-28 (10mg)PE-22-28 Vial / standard 10 $55.25 $5.53 in stock 99/100 84 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Nationwide Peptides PE-22-28 Peptide 5mgPE-22-28 Vial / standard 5 $29.00 $5.80 in stock 94/100 98 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗Affiliate link: pepmg may earn a commission. Affiliate status never affects ranking, price order or Vendor Scores.
Nationwide Peptides PE-22-28 Peptide 10mgPE-22-28 Vial / standard 10 $58.00 $5.80 in stock 94/100 98 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗Affiliate link: pepmg may earn a commission. Affiliate status never affects ranking, price order or Vendor Scores.
Elite Miami Peptides PE-22-28 10mgPE-22-28 Vial / standard 10 $58.95 $5.90 in stock 80/100 46 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗
AMC-Essentials PE 22-28 (8mg)PE-22-28 Vial / standard 8 $47.99 $6.00 in stock 80/100 66 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh.just now View product ↗
Tydes PE 22-28 8mgPE-22-28 Vial / standard 8 $49.99 $6.25 in stock 96/100 66 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Southern Aminos PE 22-28 10MGPE-22-28 Vial / standard 10 $64.00 $6.40 in stock 74/100 10 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Core Peptides PE-22-28 – 8MGPE-22-28 Vial / standard 8 $54.00 $6.75 in stock 80/100 100 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Biotech Peptides PE-22-28 (8mg)PE-22-28 Vial / standard 8 $55.00 $6.88 in stock 80/100 160 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Orbitrex Peptide PE-22-28 10mgPE-22-28 Vial / standard 10 $69.99 $7.00 in stock 85/100 51 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Supply Kore PE-22-28 10mgPE-22-28 Vial / standard 10 $70.00 $7.00 in stock 72/100 65 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Alpha Omega Peptide PE-22-28 10mgPE-22-28 Vial / standard 10 $72.00 $7.20 in stock 90/100 78 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Atomik Labz PE-22-28 8mgPE-22-28 Vial / standard 8 $60.00 $7.50 in stock 35/100 101 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Solution Peptides PE-22-28 8mgPE-22-28 Vial / standard 8 $60.00 $7.50 in stock 35/100 164 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Welli Labs PE-22-28 5mgPE-22-28 Vial / standard 5 $49.99 $10.00 in stock 72/100 1 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
RUO.bio PE-22-28PE-22-28 · Not in price comparison Vial / standard — $38.00 — in stock 89/100 210 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Pepvida Labs PE-22-28PE-22-28 · Not in price comparison Vial / standard — $118.00 — in stock 72/100 12 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Atomik Labz PE-22-28 8mgPE-22-28 · Not in price comparison Vial / standard 8 $540.00 — in stock 35/100 101 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
Solution Peptides PE-22-28 8mgPE-22-28 · Not in price comparison Vial / standard 8 $540.00 — in stock 35/100 164 indexedVendor library; batch match not assumed Checked within 24 hoursPrice and stock were collected in the latest refresh. View product ↗
COACertificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 23 of 23 tracked sources for PE-22-28 publish a COA — 14 with at least one certificate you can open at the testing lab : Modern Research Peptides (276 at the lab) , Iron Aminos (253 at the lab) , RUO.bio (91 at the lab) , Nationwide Peptides (88 at the lab) , Paramount Peptides (81 at the lab) , Tegridy Research (81 at the lab) , Alpha Omega Peptide (71 at the lab) , Tydes (66 at the lab) , Orbitrex Peptide (32 at the lab) , Modern Aminos (19 at the lab) , Glacier Aminos (3 at the lab) , Ion Peptide (2 at the lab) , and 11 more — every one of them is a linked row in the table above. What a COA proves →
● PE-22-28 blends & stacks · 1 first-party priced by total — not $/mg
VendorBlendPrice
AMC-Essentials PE 22-28 / Selank / Semax 30mg BLEND $99.99 buy →

Multi-peptide products (e.g. BPC-157 + TB-500). We don't rank these by $/mgPrice divided by the milligrams of active compound — the like-for-like way to compare cost across different vial sizes. — a per-milligram figure across different peptides isn't comparable — so they're listed separately by total price and kept out of the headline index above.

● Research articles about PE-22-28 All research →

Published dosing for PE-22-28

Source-linked reference figures with the population and study context alongside each amount. Study arms are not a starting dose, titration schedule, or personal treatment plan. Label records refer to the named approved medicine, not vendor products.

No curated dosing record is available for PE-22-28 in this index yet. That describes our coverage, not proof that no study exists. See the research and cited studies on this page.

Research use only — this reports what an FDA label, a peer-reviewed study or a clinical-trial registry entry published, tied to its species and study context. A trial-registry figure is what a sponsor registered, not a peer-reviewed result. It is not medical advice, not a recommendation to use, and no dose here is generated by pepmg. Any dosing decision is for a qualified professional. Animal-study amounts do not establish a human dose.

Reconstitution calculator → · Converts your entered quantities; it does not select a dose or establish suitability for use.

● Peer-reviewed research · PE-22-28 source: PubMed
  1. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity PubMed ↗
    Study species not classified Frontiers in pharmacology · 2017 · PMID 28955242

    Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin…

A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.

Browse all peer-reviewed research →

▸ Why compare $/mg for PE-22-28?

Prices for this compound vary widely between vendors; comparing $/mg avoids overpaying.

▸ Reading the COA

Always check each vendor's third-party Certificate of Analysis (COA) for identity and purity.

▸ Same cluster

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Methylene Blue $1.60/mg
Pinealon $2.00/mg
Cartalax $2.00/mg
Cardiogen $1.76/mg
Testagen $2.00/mg
Vilon $2.00/mg
Livagen $2.70/mg
Vesugen $2.50/mg
Prostamax $2.60/mg
Ovagen $2.70/mg
Cortagen $2.35/mg
Thymogen $3.40/mg
Chonluten $2.55/mg
Bronchogen $2.70/mg
Pancragen $3.00/mg
ACE-031 $69.99/mg
FGL $8.25/mg
IGF-1 DES $16.25/mg
→ Reconstitution calculator for PE-22-28 research math.
All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label, a peer-reviewed study or a clinical-trial registry entry has published a dose, pepmg reports it with the source named and the tier labeled (a registry figure is marked trial registry, not peer-reviewed), because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.