● pepmg Research Desk · Peer-reviewed evidence review
What the research says about PE-22-28
A neutral review of PE-22-28, a seven-amino-acid spadin analogue studied in cellular and mouse models of TREK-1 signaling. No human trials were identified. Research use only.
Preclinical only — Animal or in-vitro studies only — no controlled human trials. This describes the state of the published literature, not a claim that this compound works, is safe, or is for human use. Research use only.
The short version
- PE-22-28 is a seven-amino-acid fragment designed from degradation products of spadin and studied as an inhibitor of the TREK-1 potassium channel [1].
- The directly identified evidence consists of one publication reporting cell experiments and mouse behavioral models; it is preclinical, not evidence of an effect in people [1].
- No controlled human trial or human safety dataset was identified. Research use only; this is not medical advice or a recommendation.
What PE-22-28 is
PE-22-28 is described as a shortened spadin analogue. The cited investigators designed the seven-amino-acid peptide after studying spadin degradation products, then compared its TREK-1-channel activity and stability with the parent peptide [1].
Vendor availability does not establish identity, purity, safety, or clinical utility. The compound is not an approved medicine.
What the research measured
Preclinical onlyThe publication reports patch-clamp experiments in engineered cells, experiments in mouse cortical neurons, and behavioral tests in mice. It reports TREK-1 inhibition, changes in markers of neurogenesis and synaptogenesis, and behavioral-model outcomes [1]. These endpoints do not establish antidepressant efficacy in humans.
Only one directly relevant PubMed record was identified, so independent replication and the breadth of the evidence base are limited.
Evidence and safety boundary
Preclinical onlyNo controlled human studies or systematic human adverse-event data were identified. The honest evidence ceiling is preclinical, and no dosing or safety conclusion can be drawn for people.
This page maps the published evidence. It is not medical advice, an efficacy claim, or a recommendation to use PE-22-28.
Evidence boundary
What this research cannot tell us
- Only one directly relevant publication was identified, which limits independent replication and the breadth of conclusions [1].
- The experiments were conducted in engineered cells, mouse neurons, and mouse behavioral models rather than controlled human trials [1].
- The cited investigation studied research material prepared for its experiments, not products offered by any vendor currently tracked here [1].
Sources · 1
pepmg summarizes the peer-reviewed literature and links to every source — it sells nothing, ships nothing, and gives no medical or human-use guidance. Don't just trust this summary: follow any citation to its source and read it yourself. Research use only.