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NAD+Longevity coenzyme

Compound dossier · evidence, sources, and live market

NAD+

Longevity coenzyme Limited evidence 3 cited studies 95 live vendors

NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme found in all living cells, where it participates in redox reactions and serves as a substrate for enzymes involved in cellular energy metabolism and signaling. In research settings it is studied for its roles in mitochondrial function, DNA repair pathways, and cellular aging in laboratory models. This index tracks research-use-only vendor pricing for NAD+ so researchers can compare cost across suppliers.

Evidence brief

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to energy metabolism and a cosubstrate for enzymes such as the sirtuins; its tissue levels decline with age in the models reviewed.

cheapest (first-party)
$0.05/mg
highest
$0.50/mg
first-party vendors
95
Fair-price band · 95 first-party vendors · $/mg
median $0.12
$0.05cheapest $0.50highest
Comparing vendors on NAD+ can save up to $0.45/mg — the cheapest tracked is $0.05/mg, the priciest $0.50/mg.

first-party prices captured 37m ago

Compare by exact vialThe small sealed glass container a compound ships in. size: 100mg (8 vendors)250mg (3 vendors)500mg (80 vendors)700mg (3 vendors)1000mg (44 vendors)

email only when a vendor actually lowers a NAD+ price — set a $/mg to only hear when it crosses your number · one-click stop
▸ Regulatory statusUSnot approvedEUnot approvedUKnot approved

Not a drug — an endogenous coenzyme sold as a dietary supplement; injectable/compounded forms are not FDA-approved.Research use only — not medical advice.

NAD+ · market statistics 95 sources tracked

These figures are what pepmg still publishes about price: the floor, the middle, the spread and how many sources we track, computed from listings we captured first-party and refreshed on the same schedule as always. We no longer publish the individual listings or the sellers behind them.

lowest tracked $0.05/mg
median $0.12/mg
highest tracked $0.50/mg
spread 10×
Lowest tracked $/mg, 38 days 50% cheaper over the period
07/01 · $0.10 low $0.05 · high $0.10 08/16 · $0.05

Computed from 142 in-stock listings across 95 sources we captured first-party, with bulk vials, blends and statistical outliers excluded so the figures compare like with like. The spread is the highest tracked price divided by the lowest — how much the same milligram varies depending on where you look. The chart is the daily minimum; days we did not capture are left out rather than filled in.

COACertificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 79 of 95 sources selling NAD+ publish a COA — 44 with at least one certificate you can open at the testing lab. What a COA proves →
Independent lab tests: Finnrick's batch purity results for NAD+ → — third-party testing data, independent of every vendor and of pepmg.
Blends & stacks: 6 first-party multi-peptide products contain NAD+ , priced $47.00–$891.00 per unit. We don't rank these by $/mgPrice divided by the milligrams of active compound — the like-for-like way to compare cost across different vial sizes. — a per-milligram figure across different peptides isn't comparable — so they stay out of the figures above.
Research articles about NAD+ All research →
Peer-reviewed research · NAD+source: PubMed
  1. NAD(+) metabolism and its roles in cellular processes during ageing PubMed ↗
    ReviewhumanNature reviews. Molecular cell biology · 2021 · PMID 33353981

    Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose)…

  2. NAD⁺ in aging, metabolism, and neurodegeneration PubMed ↗
    ReviewhumanScience · 2015 · PMID 26785480

    Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a…

  3. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update PubMed ↗
    ReviewhumanAdvances in nutrition · 2023 · PMID 37619764

    The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well recognized. As the NAD+ concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD+…

A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.

Browse all peer-reviewed research →

Why compare $/mg for NAD+?

Per-mg NAD+ prices vary because vendors differ in source material, stated purity, lot testing, and vial sizes, and because NAD+ is often sold in a wide range of quantities that change the effective unit cost. Comparing normalized $/mg across suppliers helps a researcher separate genuine value from packaging differences and identify outliers in either direction.

Reading the COA

For NAD+, confirm identity on the COA by mass spectrometry against the expected molecular weight (~663.4 Da for the free acid) and check HPLC purity, ideally 98%+ for research-grade material. Because NAD+ readily degrades, watch for elevated levels of common breakdown products such as nicotinamide and ADP-ribose, which indicate hydrolysis; a reputable COA reports these as named impurities rather than a single lumped figure.

FAQ

How is lyophilized NAD+ typically stored as a research material?
Lyophilized NAD+ is generally kept sealed and desiccated at low temperature (commonly -20°C or colder) and protected from light and moisture, since the compound is hygroscopic and prone to hydrolytic degradation. Vendors typically specify storage conditions on the label or COA; once reconstituted it is far less stable than the dry powder, so most protocols treat solutions as short-lived. This is general storage information for research material, not use guidance.
What is a COA and what should I check for on one for NAD+?
A Certificate of Analysis (COA) is a lot-specific document from the manufacturer reporting analytical test results for the material you receive. For NAD+, check that identity is confirmed by mass spectrometry against the expected molecular weight, that HPLC purity meets the stated threshold, and that degradation-related impurities like nicotinamide are quantified. A COA verifies what the material is, not any outcome from using it.
Why do per-mg NAD+ prices differ so much between vendors?
Differences reflect stated purity grade, extent of lot testing (full HPLC and MS panels cost more), quantity per vial, and vendor overhead and margin. Larger vials usually lower the per-mg cost, while small research quantities carry a premium. Normalizing to $/mg makes these factors comparable across suppliers so pricing outliers are easier to spot.

Same cluster

→ Reconstitution calculator for NAD+ research math.
All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label or a peer-reviewed study has published a dose, pepmg reports it with the source named, because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.