Study summary · research use only
NAD⁺ in aging, metabolism, and neurodegeneration
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all living cells that participates in reduction-oxidation reactions and serves as a cosubstrate for enzymes such as sirtuins and poly(adenosine diphosphate-ribose) polymerases. The abstract states that cellular NAD+ concentrations change during aging, and that modulation of NAD+ usage or production has been associated in the reviewed literature with prolonged health span and life span. The review discusses factors regulating NAD+ and considers whether supplementation with NAD+ precursors may represent a new therapeutic approach for aging and associated disorders, particularly neurodegenerative diseases. Species not specified.
Abstract
Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
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