● MOTS-CMitochondrial peptide

Compound dossier · evidence, sources, and live market

MOTS-c

Mitochondrial peptide Preclinical only 3 cited studies 96 live vendors

MOTS-c is a mitochondrial-derived peptide (MDP), a short 16-amino-acid sequence encoded within the mitochondrial 12S rRNA region rather than the nuclear genome. In research contexts it is studied for its role in mitochondrial signaling and cellular metabolic regulation, and it is referenced in metabolic- and aging-related research in laboratory models. This index tracks research-use-only (RUO) vendor pricing for MOTS-c to help researchers compare cost across suppliers.

Evidence brief

MOTS-c is a mitochondrial-derived peptide studied almost entirely in cell and animal models of metabolism, muscle, and aging.

read the evidence review → inspect cited studies

cheapest (first-party)

$1.40/mg

highest

$11.60/mg

first-party vendors

Fair-price band · 96 first-party vendors · $/mg

median $4.00

$1.40cheapest $11.60highest

Comparing vendors on MOTS-c can save up to $10.20/mg — the cheapest tracked is $1.40/mg, the priciest $11.60/mg.

first-party prices captured 37m ago

Compare by exact vialThe small sealed glass container a compound ships in. size: 10mg (86 vendors)20mg (18 vendors)30mg (3 vendors)40mg (45 vendors)

▸ Regulatory statusUSnot approvedEUnot approvedUKnot approved

Not approved by the FDA, EMA, or MHRA. FDA considered MOTS-C-related substances for the 503A Bulks List at its July 23, 2026 PCAC meeting.Research use only — not medical advice.

Source: FDA Pharmacy Compounding Advisory Committee · July 23–24, 2026checked 2026-07-26

● MOTS-c · market statistics 96 sources tracked

These figures are what pepmg still publishes about price: the floor, the middle, the spread and how many sources we track, computed from listings we captured first-party and refreshed on the same schedule as always. We no longer publish the individual listings or the sellers behind them.

lowest tracked $1.40/mg

median $4.00/mg

highest tracked $11.60/mg

spread 8.3×

Lowest tracked $/mg, 38 days 24% cheaper over the period

07/01 · $1.85 low $1.30 · high $1.85 08/16 · $1.40

Computed from 155 in-stock listings across 96 sources we captured first-party, with bulk vials, blends and statistical outliers excluded so the figures compare like with like. The spread is the highest tracked price divided by the lowest — how much the same milligram varies depending on where you look. The chart is the daily minimum; days we did not capture are left out rather than filled in.

COACertificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 82 of 96 sources selling MOTS-c publish a COA — 45 with at least one certificate you can open at the testing lab. What a COA proves →

Independent lab tests: Finnrick's batch purity results for MOTS-c → — third-party testing data, independent of every vendor and of pepmg.

Blends & stacks: 6 first-party multi-peptide products contain MOTS-c , priced $78.00–$891.00 per unit. We don't rank these by $/mg — a per-milligram figure across different peptides isn't comparable — so they stay out of the figures above.

● Research articles about MOTS-c All research →

What the research says about MOTS-c Preclinical only
MOTS-c is a mitochondrial-derived peptide studied almost entirely in cell and animal models of metabolism, muscle, and aging.
Read the full review →

● Peer-reviewed research · MOTS-csource: PubMed

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance PubMed ↗
StudyhumanCell metabolism · 2015 · PMID 25738459
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling…
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation PubMed ↗
ReviewhumanFrontiers in endocrinology · 2023 · PMID 36761202
Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to the nucleus during metabolic…
MOTS-c Functionally Prevents Metabolic Disorders PubMed ↗
Reviewspecies not classifiedMetabolites · 2023 · PMID 36677050
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As…

A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.

Browse all peer-reviewed research →

▸ Why compare $/mg for MOTS-c?

Per-mg prices for MOTS-c vary widely because vendors differ in synthesis scale, stated purity, lot size, and how fill quantity is priced across vial sizes. Comparing normalized $/mg across suppliers helps a researcher gauge true value rather than being misled by headline vial prices or bulk-discount framing.

▸ Reading the COA

For MOTS-c, confirm identity by mass spectrometry against the expected monoisotopic/average mass for the 16-residue sequence, and check that HPLC purity meets a stated threshold (commonly >=98% for research peptides). Watch for truncated or deletion sequences from incomplete synthesis and for acetate/TFA counter-ion or residual solvent content that can inflate net peptide weight; a net-peptide-content figure alongside the HPLC and MS data gives the most accurate basis for $/mg comparison.

▸ FAQ

How is lyophilized MOTS-c typically stored as a research material?

As a research material, lyophilized MOTS-c is generally kept sealed and protected from light, moisture, and heat, with long-term storage at freezer temperatures (commonly -20C or colder) per the supplier's COA or product sheet. Peptides are hygroscopic, so storage conditions that limit exposure to humidity help preserve the integrity of the material. This is storage information for laboratory material only, not use directions.

What is a COA and what should I check on one for MOTS-c?

A Certificate of Analysis (COA) is the vendor's lot-specific document reporting analytical results for the material shipped. For MOTS-c, the key items are a mass-spec result confirming the peptide matches the expected 16-residue sequence mass, an HPLC chromatogram with a stated purity percentage, and supporting details such as counter-ion, water content, and net peptide content. These verify identity and purity of the material, not any outcome.

Why do per-mg prices for MOTS-c differ so much between vendors?

Differences come from synthesis scale and yield, the stated purity grade, vial fill size and lot volume, and whether pricing reflects gross versus net peptide weight. Two listings can look similar while differing substantially once normalized to $/mg of actual peptide, which is why comparing on a consistent per-mg basis is more informative than comparing sticker prices.

▸ Same cluster

CJC-1295	$2.84/mg	vs MOTS-c →
Ipamorelin	$2.60/mg	vs MOTS-c →
NAD+	$0.05/mg	vs MOTS-c →
Tesamorelin	$3.70/mg	vs MOTS-c →
Sermorelin	$3.60/mg	vs MOTS-c →
Epithalon	$1.10/mg	vs MOTS-c →
SS-31	$1.42/mg	vs MOTS-c →
Humanin	$8.90/mg	vs MOTS-c →
FOXO4-DRI	$6.26/mg	vs MOTS-c →
GHRP-2	$2.13/mg	vs MOTS-c →
GHRP-6	$2.10/mg	vs MOTS-c →
Hexarelin	$4.90/mg	vs MOTS-c →
MK-677	$2.68/mg	vs MOTS-c →
MK-777	$3.45/mg	vs MOTS-c →

→ Reconstitution calculator for MOTS-c research math.

All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label or a peer-reviewed study has published a dose, pepmg reports it with the source named, because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.