Study summary · research use only
MOTS-c Functionally Prevents Metabolic Disorders
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses MOTS-c, a mitochondrial-derived peptide encoded by a short open reading frame in the mitochondrial genome's 12S rRNA region, described as regulating mitochondrial function, gene expression, and metabolic homeostasis. The authors describe MOTS-c as associated in cited research with reduced insulin resistance, prevention of obesity, improved muscle function, promoted bone metabolism, enhanced immune regulation, and postponed aging, acting mainly through activation of AICAR-AMPK signaling by disrupting the folate-methionine cycle, and regulation of genes such as GLUT4, STAT3, and IL-10. The review states it aims to summarize genes and pathways involved in MOTS-c's physiological activity, expecting this may inform new diagnostic markers and treatment approaches for metabolic disorders.
Abstract
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, enhance immune regulation, and postpone aging. MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folate-methionine cycle in cells. Recent studies have shown that the above hormonal effect can be achieved through MOTS-c regulating the expression of genes such as GLUT4, STAT3, and IL-10. However, there is a lack of articles summarizing the genes and pathways involved in the physiological activity of MOTS-c. This article aims to summarize and interpret the interesting and updated findings of MOTS-c-associated genes and pathways involved in pathological metabolic processes. Finally, it is expected to develop novel diagnostic markers and treatment approaches with MOTS-c to prevent and treat metabolic disorders in the future.
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