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● EPITHALONLongevity peptide

Compound dossier · evidence, sources, and live market

Epithalon

Longevity peptide Limited evidence 3 cited studies 64 live vendors

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied in laboratory and animal models for its interactions with telomerase activity and circadian/pineal regulation. It is sold strictly for research use only and is not approved for human or veterinary use. This index tracks research-use-only vendor pricing for Epithalon so lab buyers can compare cost across suppliers.

Evidence brief

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a pineal-gland extract and studied mainly in animal and cell models of aging, telomere biology, and the retina.

read the evidence review → inspect cited studies
cheapest (first-party)
$1.10/mg
highest
$9.20/mg
first-party vendors
64
Fair-price band · 64 first-party vendors · $/mg
median $3.30
$1.10cheapest $9.20highest
Comparing vendors on Epithalon can save up to $8.10/mg — the cheapest tracked is $1.10/mg, the priciest $9.20/mg.

first-party prices captured 37m ago

Compare by exact vialThe small sealed glass container a compound ships in. size: 10mg (48 vendors)50mg (20 vendors)

email only when a vendor actually lowers a Epithalon price — set a $/mg to only hear when it crosses your number · one-click stop
▸ Regulatory statusUSnot approvedEUnot approvedUKnot approved

Not approved by the FDA, EMA, or MHRA. FDA considered Epitalon-related substances for the 503A Bulks List at its July 24, 2026 PCAC meeting.Research use only — not medical advice.

Source: FDA Pharmacy Compounding Advisory Committee · July 23–24, 2026checked 2026-07-26

● Epithalon · market statistics 64 sources tracked

These figures are what pepmg still publishes about price: the floor, the middle, the spread and how many sources we track, computed from listings we captured first-party and refreshed on the same schedule as always. We no longer publish the individual listings or the sellers behind them.

lowest tracked $1.10/mg
median $3.30/mg
highest tracked $9.20/mg
spread 8.4×
Lowest tracked $/mg, 38 days 27% cheaper over the period
07/01 · $1.50 low $1.10 · high $1.50 08/16 · $1.10

Computed from 78 in-stock listings across 64 sources we captured first-party, with bulk vials, blends and statistical outliers excluded so the figures compare like with like. The spread is the highest tracked price divided by the lowest — how much the same milligram varies depending on where you look. The chart is the daily minimum; days we did not capture are left out rather than filled in.

COACertificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 57 of 64 sources selling Epithalon publish a COA — 30 with at least one certificate you can open at the testing lab. What a COA proves →
Independent lab tests: Finnrick's batch purity results for Epithalon → — third-party testing data, independent of every vendor and of pepmg.
Blends & stacks: 6 first-party multi-peptide products contain Epithalon , priced $62.10–$1341.00 per unit. We don't rank these by $/mgPrice divided by the milligrams of active compound — the like-for-like way to compare cost across different vial sizes. — a per-milligram figure across different peptides isn't comparable — so they stay out of the figures above.
● Research articles about Epithalon All research →
● Peer-reviewed research · Epithalonsource: PubMed
  1. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties PubMed ↗
    ReviewhumanInternational journal of molecular sciences · 2025 · PMID 40141333

    Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland…

  2. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity PubMed ↗
    StudyhumanBiogerontology · 2025 · PMID 40908429

    Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists…

  3. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro PubMed ↗
    StudyanimalAging · 2022 · PMID 35413689

    The developmental potential of oocytes decreases with time after ovulation in vivo or in vitro. Epitalon is a synthetic short peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), based on a natural peptide…

A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.

Browse all peer-reviewed research →

▸ Why compare $/mg for Epithalon?

Per-mg prices for Epithalon vary widely because vendors differ in synthesis scale, stated purity, vial size, and how lyophilization and shipping costs are bundled into the listed price. Comparing normalized $/mg across suppliers lets a researcher see the true unit cost and spot listings that look cheap only because of a small fill weight.

▸ Reading the COA

For Epithalon, confirm identity by mass spectrometry against the expected mass of the Ala-Glu-Asp-Gly tetrapeptide (molecular weight ~390.35 Da; monoisotopic mass ~390.14 Da), and check that HPLC purity meets or exceeds a stated threshold (commonly 98%+ for research material). Because it is a short peptide, watch the HPLC trace for truncation or deletion sequences (e.g., missing-residue fragments) and for residual acetate or TFA counterions, which can inflate net weight versus actual peptide content.

▸ FAQ

How is lyophilized Epithalon typically stored and handled in a lab?
As a lyophilized powder, Epithalon is generally kept sealed, desiccated, and protected from light, with long-term storage at freezer temperatures (commonly -20C or colder). Short peptides in solution are generally less stable than the dry powder, so material stability can be limited; consult the specific vendor's stated storage conditions on the label and COA. This is general material-handling information, not use guidance.
What is a COA and what should I check on one for Epithalon?
A Certificate of Analysis (COA) is a lab document describing a specific batch of material. For Epithalon, check that mass-spec confirms the correct tetrapeptide mass, that HPLC purity meets the stated percentage, and that the report lists batch/lot number, test dates, and any residual solvent or counterion content so you can verify identity and purity of the actual material you received.
Why do per-mg prices for Epithalon differ so much between vendors?
Differences come from production scale, stated purity grade, vial fill weight, and whether analytical testing (mass spec, HPLC) is included, plus packaging and shipping handling. A larger vial usually lowers $/mg, while extra testing or higher stated purity can raise it, so normalizing to cost per milligram is the clearest way to compare listings.

▸ Same cluster

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Tesamorelin $3.70/mg vs Epithalon →
Sermorelin $3.60/mg vs Epithalon →
MOTS-c $1.40/mg vs Epithalon →
SS-31 $1.42/mg vs Epithalon →
Humanin $8.90/mg vs Epithalon →
FOXO4-DRI $6.26/mg vs Epithalon →
GHRP-2 $2.13/mg vs Epithalon →
GHRP-6 $2.10/mg vs Epithalon →
Hexarelin $4.90/mg vs Epithalon →
MK-677 $2.68/mg vs Epithalon →
MK-777 $3.45/mg vs Epithalon →
→ Reconstitution calculator for Epithalon research math.
All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label or a peer-reviewed study has published a dose, pepmg reports it with the source named, because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.