Tiers name what a vendor publishes, not a verdict on any product's purity or quality.
Lab-verifiable COAs: certificates that open on the testing lab's own site (the seal's ring shows what share of them do).
Third-party COAs: certificates attributed to a third-party lab, which may be hosted only on the vendor's site.
Tiers follow the Vendor Score (90+ and 80–89), which is 87% COA evidence; the numeral in each seal is that score.
Affiliate relationships never affect tiers, selection or order. How the Vendor Score works
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied in laboratory and animal models for its interactions with telomerase activity and circadian/pineal regulation. It is sold strictly for research use only and is not approved for human or veterinary use. This index tracks research-use-only vendor pricing for Epithalon so lab buyers can compare cost across suppliers.
Evidence brief
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a pineal-gland extract and studied mainly in animal and cell models of aging, telomere biology, and the retina.
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10mg (43 vendors)50mg (22 vendors)
Not approved by the FDA, EMA, or MHRA. FDA considered Epitalon-related substances for the 503A Bulks List at its July 24, 2026 PCAC meeting.Research use only — not medical advice.
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Epithalon · all tracked vendors · all tracked peptide listings, including out-of-stock products. Prices and stock reflect the last check. Non-comparable products do not enter market rankings. Trust scores measure published evidence, not product safety.
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COACertificate of Analysis: a lab report stating a batch's measured identity and purity.Certificate of Analysis: a lab report stating a batch's measured identity and purity. availability: 69 of 78 tracked sources for Epithalon publish a COA
— 48 with at least one certificate you can open at the testing lab: Modern Research Peptides (276 at the lab), Iron Aminos (250 at the lab), Eternal Peptides (141 at the lab), EZ Peptides (136 at the lab), Peptide Partners (133 at the lab), Ameano Peptides (108 at the lab), Blank Peptides (101 at the lab), Oros Research (96 at the lab), True Research Labs (96 at the lab), RUO.bio (91 at the lab), Nationwide Peptides (88 at the lab), Nexaph (88 at the lab), and 57 more — every one of them is a linked row in the table above. What a COA proves →
Multi-peptide products (e.g. BPC-157 + TB-500). We don't rank these by $/mgPrice divided by the milligrams of active compound — the like-for-like way to compare cost across different vial sizes.Price divided by the milligrams of active compound — the like-for-like way to compare cost across different vial sizes. — a per-milligram figure across different peptides isn't comparable — so they're listed separately by total price and kept out of the headline index above.
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a pineal-gland extract and studied mainly in animal and cell models of aging, telomere biology, and the retina.
Source-linked reference figures with the population and study context alongside each amount. Study arms are not a starting dose, titration schedule, or personal treatment plan. Label records refer to the named approved medicine, not vendor products.
Dose administered in a preclinical animal study (mouse, female transgenic FVB/N HER-2/neu mice, dosed from the 2nd month of life to death)
1 mg 5 times a week
mouse · female transgenic FVB/N HER-2/neu mice, dosed from the 2nd month of life to death · preclinical animal study · Route reported: subcutaneous
Research use only — this reports what an FDA label or a peer-reviewed study published, tied to its species and study context. It is not medical advice, not a recommendation to use, and no dose here is generated by pepmg. Any dosing decision is for a qualified professional. Animal-study amounts do not establish a human dose.
Reconstitution calculator → · Converts your entered quantities; it does not select a dose or establish suitability for use.
● Peer-reviewed research · Epithalonsource: PubMed
ReviewhumanInternational journal of molecular sciences · 2025 · PMID 40141333
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland…
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists…
The developmental potential of oocytes decreases with time after ovulation in vivo or in vitro. Epitalon is a synthetic short peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), based on a natural peptide…
A few representative studies, each summarized on this site with the PubMed record linked beside it — not an endorsement or a claim that any result applies to human use. Read them and judge for yourself. Everything here is research use only.
Per-mg prices for Epithalon vary widely because vendors differ in synthesis scale, stated purity, vial size, and how lyophilization and shipping costs are bundled into the listed price. Comparing normalized $/mg across suppliers lets a researcher see the true unit cost and spot listings that look cheap only because of a small fill weight.
▸ Reading the COA
For Epithalon, confirm identity by mass spectrometry against the expected mass of the Ala-Glu-Asp-Gly tetrapeptide (molecular weight ~390.35 Da; monoisotopic mass ~390.14 Da), and check that HPLC purity meets or exceeds a stated threshold (commonly 98%+ for research material). Because it is a short peptide, watch the HPLC trace for truncation or deletion sequences (e.g., missing-residue fragments) and for residual acetate or TFA counterions, which can inflate net weight versus actual peptide content.
▸ FAQ
How is lyophilized Epithalon typically stored and handled in a lab?
As a lyophilized powder, Epithalon is generally kept sealed, desiccated, and protected from light, with long-term storage at freezer temperatures (commonly -20C or colder). Short peptides in solution are generally less stable than the dry powder, so material stability can be limited; consult the specific vendor's stated storage conditions on the label and COA. This is general material-handling information, not use guidance.
What is a COA and what should I check on one for Epithalon?
A Certificate of Analysis (COA) is a lab document describing a specific batch of material. For Epithalon, check that mass-spec confirms the correct tetrapeptide mass, that HPLC purity meets the stated percentage, and that the report lists batch/lot number, test dates, and any residual solvent or counterion content so you can verify identity and purity of the actual material you received.
Why do per-mg prices for Epithalon differ so much between vendors?
Differences come from production scale, stated purity grade, vial fill weight, and whether analytical testing (mass spec, HPLC) is included, plus packaging and shipping handling. A larger vial usually lowers $/mg, while extra testing or higher stated purity can raise it, so normalizing to cost per milligram is the clearest way to compare listings.
All products listed are sold by third-party vendors for laboratory and research use only (RUO). Where an FDA label or a peer-reviewed study has published a dose, pepmg reports it with the source named, because that is safer than guessing. It is a report, not medical advice and not a recommendation to use anything. pepmg sells nothing and ships nothing. Listings are price-tracking data, not endorsements.
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