Study summary · research use only
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review, species not specified, summarizes progress on nicotinamide mononucleotide (NMN) supplementation in human clinical trials. It notes that NAD+ concentrations in human skin, blood, liver, muscle, and brain are thought to decrease with age, and that in vitro and in vivo studies have shown NMN supplementation increases NAD+ concentration and may affect aging-related processes such as oxidative stress, DNA damage, neurodegeneration, and inflammatory responses. The authors note that most studies on NMN have been conducted in cell or animal models, so questions remain regarding its physiological effects in humans, and that a dozen human clinical trials with NMN supplementation are currently underway, with this review summarizing their progress and NMN/NAD+ biology.
Abstract
The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well recognized. As the NAD+ concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD+ status could possibly influence the aging process and associated metabolic sequelae. Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis, and in vitro/in vivo studies have demonstrated that NMN supplementation increases NAD+ concentration and could mitigate aging-related disorders such as oxidative stress, DNA damage, neurodegeneration, and inflammatory responses. The promotion of NMN as an antiaging health supplement has gained popularity due to such findings; however, since most studies evaluating the effects of NMN have been conducted in cell or animal models, a concern remains regarding the safety and physiological effects of NMN supplementation in the human population. Nonetheless, a dozen human clinical trials with NMN supplementation are currently underway. This review summarizes the current progress of these trials and NMN/NAD+ biology to clarify the potential effects of NMN supplementation and to shed light on future study directions.
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