Study summary · research use only
[Investigation of antihypoxic properties of short peptides]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study investigated antihypoxic properties of short regulatory peptides (vilon, epitalon, vesugen, and pinealon) using a model of hypobaric hypoxia; the abstract does not specify the species. The authors report that the peptides showed antihypoxic properties in this model, with pinealon (Glu-Asp-Arg) described as having the most pronounced effect. They state that pinealon's capacity to increase neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex basis, resting not so much on inhibition of reactive oxygen species increase in response to stress as on stimulation of an internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate. No numerical figures were provided in the abstract.
Abstract
The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia. Pinealon (Glu-Asp-Arg) has the most pronounced effect among them. The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature. It is based not so much on the inhibition of ROS increase in cells in response to stress as on stimulation of internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate.
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