Study summary · research use only
The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study examined effects of acute intravenous synthetic DSIP (delta-sleep-inducing-peptide), 25 nmoles/kg body weight, on disturbed sleep in 6 middle-aged chronic insomniacs. The abstract reports longer sleep duration, higher sleep quality with fewer interruptions, and slightly more REM sleep, without day-time sedation or other side effects, with the sleep-enhancing pattern observed for up to 6 h of night sleep. Sleep-promoting effects were reported only in the second hour after injection, with a slight arousing effect indicated in the first hour. The authors described the findings as corroborating prior studies in healthy subjects and indicating a normalizing influence of DSIP on human sleep regulation.
Abstract
The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs. The results were: longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep. Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated. The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.
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