Study summary · research use only
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study examined acute and delayed effects of intravenous synthetic delta sleep-inducing peptide (DSIP) on sleep behavior in six normal volunteers (four males, two females) using a double-blind cross-over design, with DSIP infused slowly at 25 nmol/kg in the morning. Subjects reported an immediate feeling of sleep pressure, and sleep increased by 59% (median total sleep time) within a 130-min interval versus placebo. Delayed effects on subsequent night sleep included shorter sleep onset, reduced stage 1 percentage, and better sleep efficiency, though behavioral and EEG analyses showed no classic pharmacologic sedation. The authors reported the compound was tolerated without observed psychologic, physiologic, or biochemical side effects.
Abstract
A first study of DSIP (= synthetic delta sleep-inducing peptide) application to humans was carried out in six normal volunteers (four males and two females) under extensive psychophysiologic observations and measurements in a double-blind cross-over design. DSIP was applied as slow intravenous infusions at a dosage of 25 nmol/kg in the morning. The subjects immediately reported a feeling of sleep pressure, and sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo. Delayed effects on subsequent night sleep were shorter sleep onset, reduced percentage of stage 1, and better sleep efficiency. Nevertheless, sophisticated behavioral and EEG analyses revealed no sedation in the classic pharmacologic way. The results suggest that DSIP in humans is also efficacious by sustaining natural sleep functions. The compound was well-tolerated and no psychologic, physiologic, or biochemical side effects were observed.
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