Study summary · research use only
Some pharmacological effects of delta-sleep-inducing peptide (DSIP)
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study in rabbits, cats, and morphine-dependent mice examined pharmacological effects of synthetic delta-sleep-inducing peptide (DSIP) under normal and disturbed-sleep conditions. In rabbits, DSIP at 25 micrograms/kg IV and 1 mg/kg SC was associated with augmented spindle-dominated, light nonREM sleep and prevention of hyposomnia after stress. In cats, 25 micrograms/kg IV and 100 micrograms/kg SC were associated with preferentially augmented REM sleep and abolition of morphine's sleep-suppressant effect. In morphine-dependent mice, 25.5 micrograms/kg IV and doses beyond 85 micrograms/kg SC were associated with attenuated naloxone-induced withdrawal jumping. The authors reported bell-shaped dose-response curves for DSIP in most experimental situations.
Abstract
The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep. In other experiments, the effect of the oligopeptide on withdrawal jumping provoked by naloxone in morphine-dependent mice was studied. In rabbits, DSIP at 25 micrograms X kg-1 i.v. and 1 mg X kg-1 s.c. augmented spindle-dominated, light nonREM sleep and prevented hyposomnia after a stressful situation. In cats, 25 micrograms X kg-1 i.v. and 100 micrograms X kg-1 s.c. preferentially augmented REM sleep and abolished the sleep suppressant effect of morphine. In morphine-dependent mice, 25.5 micrograms X kg-1 i.v. as well as doses beyond 85 micrograms X kg-1 s.c. attenuated naloxone-induced withdrawal jumping. In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.
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