Study summary · research use only
Delta-sleep-inducing peptide (DSIP): a review
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article discusses delta-sleep-inducing peptide (DSIP), a nonapeptide of MW 849 described as inducing mainly delta-sleep in rabbits, rats, mice, and humans, with a more pronounced effect on REM sleep reported in cats. The review states a U-shaped activity curve was determined for both dose and timing of infusion. DSIP-like material was reported by RIA and immunohistochemistry in brain and peripheral organs of the rat, and in plasma of several mammals. The review also describes reported associations between DSIP and electrophysiological activity, brain neurotransmitter levels, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
Abstract
Since the turn of the century, it has been postulated that humoral factors induce sleep. Many compounds were proposed as sleep-factors, but only two of the sleep-peptides have been purified to homogeneity and characterized, so far. One of them, DSIP, was shown to be a nonapeptide of MW 849 and to induce mainly delta-sleep in rabbits, rats, mice, and humans, whereas in cats, the effect on REM sleep was more pronounced. A U-shaped activity curve was determined for the dose as well as for the time of infusion. DSIP-like material was found by RIA and immunohistochemistry in brain and by RIA in peripheral organs of the rat as well as in plasma of several mammals. In addition to sleep, the peptide also has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
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