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Study summary · research use only

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice.

Study · animal · Cell metabolism · 2025 · DOI 10.1016/j.cmet.2025.07.004 · PMID 40769122

Abstract

Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.

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