Study summary · research use only
Role of MOTS-c in the regulation of bone metabolism
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (species not specified; a literature review, not a specific trial) discusses MOTS-c, a mitochondrial-derived peptide (MDP) described as involved in cell protection, energy metabolism, and specific diseases. The authors describe studies reporting that MOTS-c is associated with osteoblast proliferation, differentiation, and mineralization, and with inhibition of osteoclast production, and state that exercise upregulates MOTS-c expression, though the specific mechanism linking exercise-induced MOTS-c to bone regulation remains unclear. The review summarizes the distribution and function of MOTS-c in tissue, recent findings on osteoblast and osteoclast regulation, and proposed mechanisms for exercise effects on bone metabolism, describing itself as a theoretical reference for future approaches to skeletal metabolic disease.
Abstract
MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the expression of MOTS-c, but the specific mechanism of MOTS-c regulation in bone by exercise remains unclear. Therefore, this article reviewed the distribution and function of MOTS-c in the tissue, discussed the latest research developments in the regulation of osteoblasts and osteoclasts, and proposed potential molecular mechanisms for the effect of exercise on the regulation of bone metabolism. This review provides a theoretical reference for establishing methods to prevent and treat skeletal metabolic diseases.
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