Study summary · research use only
Kisspeptin as a predictor of miscarriage: a systematic review
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This systematic review searched PubMed/Medline, Embase, Web of Science, and Scopus databases for studies on kisspeptin as a biomarker of miscarriage in humans. Seven case-control studies were selected for inclusion, describing a potential role for kisspeptin as a marker of pregnancy loss, and two of these studies reported that changes in kisspeptin levels may be associated with unexplained infertility and lower rates of embryo implantation in women undergoing assisted reproductive technology. The authors describe kisspeptin as a potential future biomarker of pregnancy viability, while stating that studies with stronger evidence are needed to establish its use as a diagnostic and prognostic tool.
Abstract
A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose. This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databases using the following keywords: (kisspeptin) AND (miscarriage OR pregnancy loss OR spontaneous abortion OR reproductive failure). Seven case-control studies were selected for the systematic review. The included papers described the potential role of kisspeptin as a putative biomarker of pregnancy loss. Furthermore, two studies reported that changes in kisspeptin levels may be associated with unexplained infertility and low rates of embryo implantation in women undergoing assisted reproductive technology. Kisspeptin might be used as a potential biomarker of pregnancy viability in the near future. However, studies with better evidence are needed to establish the applicability of kisspeptin as a diagnostic and prognostic tool.
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