Study summary · research use only
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses mitochondrial-encoded peptides, including MOTS-c (from the 12S ribosomal RNA), humanin and short humanin-like peptides 1-6 (SHLP1-6, from 16S rRNA), and SHMOOSE, in relation to cellular metabolism and insulin action in age-related diseases such as type 2 diabetes mellitus. The review focuses mainly on recent MOTS-c research relevant to type 1 and type 2 diabetes, and states that emerging understanding of MOTS-c in diabetes may provide insight into developing new therapies for diabetes and other age- or senescence-related diseases.
Abstract
Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.
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