Study summary · research use only

The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat

Study · animal · Physiology & behavior · 1987 · DOI 10.1016/0031-9384(87)90098-9 · PMID 3671519

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

In this study of 8 cats, subcutaneous injection of delta sleep-inducing peptide (DSIP) at 120 nmol.kg-1 was examined for effects on sleep, using polygraphic EEG, electro-oculography (EOG), and electromyography (EMG) recordings over 8 hours. DSIP was associated with a significant increase in slow-waves (delta sleep) in the sleep EEG compared with Ringer injection controls. There was a tendency toward reduced waking time, prolonged slow wave sleep time, and shortened sleep onset and REM sleep latencies, though these differences were not statistically significant, and there was no change in the amount of REM sleep. The authors describe these findings as supporting the idea that DSIP can increase sleep wave activity when given peripherally.

Abstract

Delta sleep inducing peptide (DSIP) significantly increases deep-slow-wave sleep (DSWS) of cats after subcutaneous (SC) injection. Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours. DSIP was found to significantly increase slow-waves (delta sleep) in the sleep EEG. There was a tendency to reduced waking time and a prolongation of slow wave sleep time, and a shortening of sleep onset and REM sleep latencies but the differences from control (Ringer injection) were not statistically significant. There was no change in the amount of REM sleep. These findings support the belief that DSIP can increase sleep wave activity when administered by peripheral route.

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