Study summary · research use only
Current Perspectives on Kisspeptins Role in Behaviour
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the neuropeptide kisspeptin's roles beyond reproduction, drawing on animal and human data. The abstract describes kisspeptin and its receptor as distributed in extra-hypothalamic brain regions and reports that recent studies show kisspeptin is associated with behaviours including olfactory-mediated partner preference, sexual motivation, copulatory behaviour, bonding, mood, and emotions. The authors state the review provides an update on animal and human literature regarding kisspeptin's behaviour- and mood-related roles, and note that understanding this biology is relevant to the development of kisspeptin-based approaches for reproductive and related psychological and psychosexual disorders. Species not uniformly specified (review covers both animal and human studies).
Abstract
The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions. An expanding pool of animal and human data demonstrates that kisspeptin sits within an extensive neuroanatomical and functional framework through which it can integrate a range of internal and external cues with appropriate neuroendocrine and behavioural responses. In keeping with this, recent studies reveal wide-reaching effects of kisspeptin on key behaviours such as olfactory-mediated partner preference, sexual motivation, copulatory behaviour, bonding, mood, and emotions. In this review, we provide a comprehensive update on the current animal and human literature highlighting the far-reaching behaviour and mood-altering roles of kisspeptin. A comprehensive understanding of this important area in kisspeptin biology is key to the escalating development of kisspeptin-based therapies for common reproductive and related psychological and psychosexual disorders.
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