Study summary · research use only
Delta-sleep-inducing peptide (DSIP): an update
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This paper (species not specified overall, discussing prior animal and human-relevant literature) reviews reports on delta-sleep-inducing peptide (DSIP) published in the two years since a 1984 review covering its isolation and characterization from 1963 to 1977 and its early sleep and extra-sleep effects. The authors describe additional reports of sleep-inducing and supporting effects of DSIP in animals, along with work evaluating potential therapeutic uses such as treatment of insomnia, pain, and withdrawal. Immunohistochemical and radioimmunochemical studies are described as providing further insight into the natural occurrence and distribution of DSIP-like material in the body, suggesting possible relations to certain diseases. The authors state that DSIP's physiological functions and a possible mechanism involving modulation of adrenergic transmission remain to be established.
Abstract
The isolation and characterization of delta-sleep-inducing peptide (DSIP) achieved from 1963 to 1977 were reviewed in 1984. The first reports describing sleep as well as extra-sleep effects of DSIP also were included in that work. Only two years later, much additional literature concerning DSIP has accumulated. Besides further sleep-inducing and/or -supporting effects of DSIP in animals, considerable work has been carried out to evaluate the potential use of the peptide for therapeutic purposes such as treatment of insomnia, pain, and withdrawal. Immunohistochemical as well as radioimmunochemical studies provided further insights into the natural occurrence of the nonpeptide and the distribution of DSIP-like material in the body, suggesting possible relations of the peptide to certain diseases. Various physiological functions of DSIP and a possible mechanism of action involving the modulation of adrenergic transmission remain to be established.
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