Study summary · research use only
Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study using ovariectomized rats, researchers tested whether delta sleep-inducing peptide (DSIP) affects luteinizing hormone (LH) release. Intraventricular DSIP (2 or 10 micrograms) did not affect LH release in ovariectomized rats alone, but in two separate experiments DSIP (2 or 10; 15 or 30 micrograms) stimulated LH release in ovariectomized, estrogen- and progesterone-primed rats. DSIP (10(-8) or 10(-6)M) had no effect on basal or luteinizing hormone-releasing hormone-induced LH release from hemipituitaries of ovarian steroid-primed rats in vitro. The authors state these findings are consistent with the hypothesis that DSIP or DSIP-like peptides may activate hypothalamic circuitry involved in LH release during sleep.
Abstract
Delta sleep inducing peptide (DSIP) has been shown to increase sleep in various animals and it is found in various parts of the brain including the hypothalamus. While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release in ovariectomized rats, in two separate experiments DSIP (2 or 10; 15 or 30 micrograms) promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats. However, DSIP (10(-8) or 10(-6)M) had no effect on either basal or luteinizing hormone-releasing hormone-induced in vitro LH release from the hemipituitaries of ovarian steroid-primed rats. These findings are in accord with the hypothesis that DSIP or DSIP-like peptide(s) may activate the hypothalamic neural circuitry responsible for stimulation of LH release reported to occur during sleep.
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