Study summary · research use only
Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of Sprague-Dawley (SD) rats, researchers examined intranasal delta sleep-inducing peptide (DSIP) treatment before and after focal stroke induced by intraluminal middle cerebral artery occlusion (MCAO). Groups included MCAO plus vehicle, MCAO plus DSIP, and SHAM-operated rats; DSIP or vehicle was given nasally 60 (±15) minutes before occlusion and daily for 7 days after reperfusion at a dose of 120 µg/kg. Behavioral tests assessing motor coordination, balance, and bilateral asymmetry were performed on days 1, 3, 7, 14, and 21 after MCAO, and infarction volume was calculated from brain cryoslices. Brain infarction was smaller in DSIP-treated animals than vehicle-treated animals, though the difference was not significant, while motor performance in the rotarod test was significantly better recovered in DSIP-treated animals.
Abstract
Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.
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