Study summary · research use only
Functional Connectomic Approach to Studying Selank and Semax Effects
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study used resting-state fMRI to examine effects of the peptides Selank and Semax on whole-brain functional connectivity (FC) in 52 healthy participants, focusing on the amygdala and dorsolateral prefrontal cortex (DLPFC) in each hemisphere. Scans were performed before and after 5 and 20 min following injection of Semax, Selank, or placebo. The authors report between-group and between-condition differences in FC between the right amygdala and a region spanning fusiform, inferior and middle temporal, and parahippocampal gyri in the right hemisphere, and describe post hoc findings characterizing effects of Selank and Semax on FC between the right amygdala and right temporal cortex.
Abstract
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal cortex (DLPFC; the key region for executive functions, including working memory) in the right and left hemisphere. Resting-state fMRI was carried out three times, namely before, after 5 and 20 min of the injection of either Semax, or Selank, or placebo. Between-group alongwith between-condition differences were revealed in FC between the right amygdala and a region in fusiform, inferior and middle temporal as well as parahippocampal gyri in the right hemisphere. Post hoc analysis allowed us to define both general and specific effects of Selank and Semax on FC between the right amygdala and the right temporal cortex for the first time.
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