Study summary · research use only
Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined methylene blue in a model of focal unilateral traumatic brain injury in the sensorimotor cortical region, which disturbed functions of the contralateral limbs. A single intravenous injection of methylene blue (1 mg/kg), given immediately before or 30 min after the injury, was associated with reduced functional disorders in the affected extremities. In vitro experiments showed methylene blue reduced death of cultured neurons caused by paraquat or zinc ions, which produce toxic effects on mitochondria. Species not specified.
Abstract
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
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