Study summary · research use only
Glutathione Utilization in Lactobacillus fermentum CECT 5716
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this laboratory study of the bacterium Lactobacillus fermentum CECT 5716, the authors characterized cellular activity related to glutathione, a tripeptide antioxidant reported to be utilized or synthesized by some Gram-positive bacteria including lactic acid bacteria. The study reports that L. fermentum CECT 5716 had a better survival rate in the presence of glutathione under oxidative and metal stress conditions. Although this strain was reported to lack the ability to synthesize glutathione under the conditions tested, it was shown to take up both reduced and oxidized glutathione from the environment, regenerate reduced glutathione from oxidized glutathione, and secrete glutathione into the environment.
Abstract
Glutathione, a tripeptide antioxidant, has recently been shown to be either utilized or synthesized by Gram-positive bacteria, such as lactic acid bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding glutathione in Lactobacillus fermentum CECT 5716 is characterized. We demonstrate that L. fermentum CECT 5716 has a better survival rate in the presence of glutathione under both oxidative and metal stress. As L. fermentum CECT 5716 does not possess the ability to synthesize glutathione under the conditions tested, it shows the ability to uptake both reduced and oxidized glutathione from the environment, regenerate reduced glutathione from oxidized glutathione, and perform secretion of glutathione to the environment.
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