Study summary · research use only
Effects of Semax on the Default Mode Network of the Brain
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this human study of healthy volunteers (11 men and 13 women aged 43.9±9.5 years), the effects of the nootropic drug Semax on the brain's default mode network were examined using resting state functional magnetic-resonance imaging (fMRI). Resting state fMRI was performed 3 times: before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects). The topography of the resting state default mode network was studied, and a greater volume of the default mode network rostral (medial frontal cortex) subcomponent was found in the Semax group compared with controls. The authors report that resting state fMRI confirmed Semax effects on the brain's neuronal network and demonstrated the topography of these effects.
Abstract
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years). Resting state fMRI was carried out 3 times: directly before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects). The topography of the resting state default mode network was studied. A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.
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