Study summary · research use only
Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (species not specified) evaluates existing literature on stocking Methylene Blue (MB) as an emergency antidote, noting that stocking is reported in the United States, Japan, Greece, Italy, and Canada. The authors state MB is described as the main antidote required in emergency and critical care units, and revisit its effects on the NO/cGMP system to discuss its actions across multiple systems. The review covers MB's role in emergency units regarding: polytrauma and circulatory shock; neuroprotection; anaphylaxis; and overdose and poisoning.
Abstract
Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.
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