Study summary · research use only
Mitochondrially derived peptides as novel regulators of metabolism
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article discusses mitochondrially derived peptides as a class of circulating signaling molecules, including humanin, the first identified member, along with newer members MOTS-c and SHLP1-6. The abstract describes humanin as associated with effects such as reduced weight gain and visceral fat and increased glucose-stimulated insulin release in prior studies, and states that MOTS-c was associated with decreased weight gain in mice fed a high-fat diet. The review covers the basic biology of this peptide class and discusses relevance to whole-body metabolism.
Abstract
Mitochondrially derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose-stimulated insulin release. The discovery of several other new members, such as MOTS-c and SHLP1-6, has further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high-fat diet. This review covers the basic biology of this class of peptides and discusses the relevance to organismal metabolism.
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