Study summary · research use only
Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP)
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study in mice and rats examined the effect of centrally administered delta-sleep-inducing peptide (DSIP) on nociceptive responses. In mice, DSIP given intracerebroventricularly or intracisternally produced a dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests, while intrathecal administration did not produce this effect. The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist naloxone, and DSIP did not produce an antinociceptive effect in morphine-tolerant mice. Similar antinociceptive effects were observed in rats. The authors suggest DSIP acts at the supraspinal level, mediated via the opioid receptor either directly or indirectly, and may play a role in pain regulation in the central nervous system.
Abstract
The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats. DSIP, administered intracerebroventricularly or intracisternally to mice, produced a significant dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests. Intrathecal administration of DSIP did not produce such an effect. The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist, naloxone. Moreover, DSIP did not produce an antinociceptive effect in morphine-tolerant mice. Similar antinociceptive effects of DSIP were observed in rats. These results suggest that DSIP produces an antinociceptive effect by acting at the supraspinal level and that this effect is mediated via the opioid receptor, either directly or indirectly. DSIP may play an important role in pain regulation in the central nervous system.
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