Study summary · research use only
[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of 18-month aged rats subjected to two stress models, acute hypobaric hypoxia and mild hypothermia, the authors compared the peptide preparations Cortexin and Pinealon on behavioral and neurochemical measures. Cortexin was associated with a more pronounced effect on free radical processes and caspase 3 activity in the brain than Pinealon. Both preparations were associated with increased accumulation of adrenergic mediator in the rats' brains in the hypobaric hypoxia model, and of serotonin in the cerebral cortex in the mild hypothermia model, which the authors suggest may underlie geroprotective effects.
Abstract
The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have been identified. Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon. Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects. Исследовано влияние Кортексина и Пинеалона в двух моделях стресса — острой гипобарической гипоксии и умеренной гипотермии у 18-месячных крыс. Выявлены особенности влияния пептидных препаратов на поведенческие и нейрохимические показатели. Кортексин оказывает более выраженное действие на свободнорадикальные процессы и активность каспазы 3 в мозгу, чем Пинеалон. Оба препарата способствуют накоплению адренергических медиаторов в мозгу крыс в модели острой гипобарической гипоксии, а также серотонина в коре больших полушарий при умеренной гипотермии, что может лежать в основе их геропротекторных эффектов.
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