Study summary · research use only
Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) in gut endocrine cells of humans, rats, and pigs, using antisera against synthetic DSIP. The abstract reports that DSIP-LI was found in gastrin/CCK, secretin, and PYY/glicentin cells in human gut, which was described as the richest source, with a moderate number of immunoreactive cells in the antral mucosa of rat and pig gut and very few in the intestines of both species. Radioimmunoassay showed the highest DSIP-LI concentrations in human specimens compared with corresponding pig and rat samples, and high-performance liquid chromatography in all three species revealed a single peak of DSIP-like material with a retention time similar to DSIP 3-9.
Abstract
Delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) has previously been demonstrated in brain neurons and in endocrine cells of the pituitary and the adrenal medulla. By means of three different antisera against synthetic DSIP we now describe the occurrence and distribution of DSIP-LI in several gut endocrine cells. The human gut was the richest source, where DSIP-LI was located in gastrin/CCK, secretin and PYY/glicentin cells. The rat and pig gut harbour a moderate number of immunoreactive cells in the antral mucosa but in the intestines DSIP-LI-containing cells were very few. By radioimmunoassay, the concentration of DSIP-LI was determined in extracts of various gut regions from man, pig and rat. The highest concentrations were found in all human specimens compared with corresponding samples in the pig and rat. In all three species, high-performance liquid chromatography revealed a single peak of DSIP-like material with approximately the same retention time as DSIP 3-9. Taken together, the present results provide evidence for the presence of DSIP-LI in gut endocrine cells in man, pig and rat; the human gut seems to be the richest source of DSIP-like peptides.
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