Study summary · research use only
There is Kisspeptin - And Then There is Kisspeptin
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses kisspeptin and its receptor KISS1R. The abstract notes kisspeptin was initially identified as a metastasis suppressor and, after identification of KISS1R and their tissue expression, was assigned endocrine functions including regulation of puberty and fertility through hypothalamic gonadotropin-releasing hormone production. It describes a more recently recognized role in regulating glucose homeostasis, insulin secretion, food intake and body composition, noting that deficient kisspeptin signaling was associated with reduced locomotor activity and increased adiposity. The authors highlight these observations on kisspeptin in metabolism and several key questions to be addressed in the future.
Abstract
While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. This review highlights these recent observations on the role of kisspeptin in metabolism as well as several key questions that need to be addressed in the future.
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