Study summary · research use only
[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review and data article discusses the cytokines CCL11 (eotaxin) and HMGB1 (alarmin1) as molecular markers of ageing and neurological, cardiovascular and immune diseases. The abstract describes short peptides developed at the St. Petersburg Institute of Bioregulation and Gerontology that regulate gene expression and protein synthesis, and presents a proposed role for the dipeptide vilon (Lys-Glu) and tetrapeptide epitalon (Ala-Glu-Asp-Gly) in regulating CCL11 and HMGB1 genes, with a suggested geroprotective action realized through suppression of these genes.
Abstract
Cytokines CCL11 (eotaxin) and HMGB1 (alarmin1) are molecular markers of ageing and neurological, cardiovascular and immune diseases. Created in St. Petersburg Institute of Bioregulation and Gerontology short peptides are known to regulate gene expression and protein synthesis. They promote the mortality decrease and slowdown the development of pathology in the elderly. The article presents the proposed role of dipeptide vilon (Lys-Glu) and tetrapeptide epitalon (Ala-Glu-Asp-Gly) in CCL11 and HMGB1 genes regulation as activators of their expression. Geroprotective action of vilon and epitalon probably realizes in suppression of these genes.
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