Study summary · research use only
Delta-sleep inducing peptide entrapment in the charged macroporous matrices
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined entrapment of delta-sleep-inducing peptide (DSIP) in two macroporous polymer matrices: a dimethylaminoethyl methacrylate copolymer (Co-DMAEMA-MBAA) and an acrylic acid copolymer (Co-AA-MBAA). The abstract reports that nearly 100% of DSIP was entrapped into the positively charged Co-DMAEMA-MBAA matrix, while only 2-6% adsorbed onto the negatively charged Co-AA-MBAA. DSIP release from Co-DMAEMA-MBAA was observed in saline solutions (0.9% NaCl and PBS) but not in water or 25% ethanol, indicating that ionic strength drove the release process.
Abstract
Various biomolecules, for example proteins, peptides etc., entrapped in polymer matrices, impact interactions between matrix and cells, including stimulation of cell adhesion and proliferation. Delta-sleep inducing peptide (DSIP) possesses numerous beneficial properties, including its abilities in burn treatment and neuronal protection. DSIP entrapment in two macroporous polymer matrices based on copolymer of dimethylaminoethyl methacrylate and methylen-bis-acrylamide (Co-DMAEMA-MBAA) and copolymer of acrylic acid and methylen-bis-acrylamide (Co-AA-MBAA) has been studied. Quite 100% of DSIP has been entrapped into positively charged Co-DMAEMA-MBAA matrix, while the quantity of DSIP adsorbed on negatively charged Co-AA-MBAA was only 2-6%. DSIP release from Co-DMAEMA-MBAA was observed in saline solutions (0.9% NaCl and PBS) while there was no DSIP release in water or 25% ethanol, thus ionic strength was a reason of this process.
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