Study summary · research use only
[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the authors examined effects of Cortexin and Pinealon (Glu-Asp-Arg) on caspase-3 activity in the brain and interleukin-6 and tumor necrosis factor in blood serum of old rats under sharp hypoxic hypoxia. The abstract suggests that under brain hypoxia Pinealon promoted increased neurogenesis and decreased neuroinflammatory reactions toward a reference level, while Cortexin reduced the capacity for programmed cell death in brain tissue but kept interleukin-6 content at a high level.
Abstract
While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.
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