Study summary · research use only
Methylene blue unresponsive methemoglobinemia
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This case report (species not specified in the abstract) describes a patient with acquired methemoglobinemia, a blood disorder the authors attribute to exposure to certain oxidizing agents and drugs. The report notes that a history of toxin ingestion may be absent and that pulse-oximetry and blood gas analysis can aid diagnosis. In this reported case of severe toxic methemoglobinemia, the authors describe that the condition did not respond to methylene blue therapy and was subsequently managed with exchange transfusion. No quantitative outcomes are reported in the abstract.
Abstract
Acquired methemoglobinemia is an uncommon blood disorder induced by exposure to certain oxidizing agents and drugs. Although parents may not give any history of toxin ingestion; with the aid of pulse-oximetry and blood gas analysis, we can diagnose methemoglobinemia. Prompt recognition of this condition is required in emergency situations to institute early methylene blue therapy. We report an unusual case of severe toxic methemoglobinemia, which did not respond to methylene blue, but was successfully managed with exchange transfusion.
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