Study summary · research use only
Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this human study, the authors measured delta sleep-inducing peptide (DSIP)-like and phosphorylated P-DSIP-like immunoreactivity by radioimmunoassay in cerebrospinal fluid of patients with senile dementia of the Alzheimer type (subdivided into early, middle and late), multi-infarct dementia, Parkinson's disease, vascular disease, communicating hydrocephalus, and control patients. The abstract reports that mean DSIP-like and P-DSIP-like concentrations were significantly higher in the elderly control group (mean age 83 +/- 5 years) than the middle-aged control group (mean age 40 +/- 16 years), that both correlated positively with age, and that DSIP-like levels were significantly decreased in several patient groups versus age-matched controls, whereas P-DSIP-like showed no pathology-related differences.
Abstract
The concentrations of delta sleep-inducing peptide (DSIP)-like (DSIP-LI) and P-DSIP-like (phosphorylated, Ser7) immunoreactivity (P-DSIP-LI) were measured by specific radioimmunoassay in the cerebrospinal fluid (CSF) of patients with senile dementia of the Alzheimer type [SDAT, subdivided into early (S1), middle (S2) and late dementia (S3)], multi-infarct dementia (MD), Parkinson's disease (PD), vascular disease (VD) and communicating hydrocephalus (H), as well as in control patients (C1, C2). Mean DSIP-LI and P-DSIP-LI concentrations were found to be significantly higher in the elderly control group (C1, mean age 83 +/- 5 years) than in the middle-aged control group (C2, mean age 40 +/- 16 years). DSIP-LI and P-DSIP-LI were positively correlated with age in both control groups. Significant decreases of DSIP-LI compared with age-matched controls (C1) were observed for S2, S3, MD, PD, VD and H. In contrast, no significant differences corresponding to pathology were found for P-DSIP-LI.
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