Study summary · research use only
[Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses experimental data from mice and rats on the remote effects of neonatal injections of biologically active drugs, including the ACTH(4-10) fragment and its analogue Semax, along with piracetam, caffeine, levetiracetam, and busperone. The authors describe that these neonatal treatments produced detectable changes in adult animals' physiological and behavioral reactions and morphological traits, including audiogenic seizure proneness, anxiety-fear and exploration behavior, and pain sensitivity, with remote effects sometimes similar in direction to adult-administered effects and sometimes opposite. The authors suggest these treatments interfere with CNS development during early postnatal ontogeny, presumably via changes in neurotransmitter system development, capable of inducing CNS morphological deviations such as altered neuron numbers and adult neurogenesis.
Abstract
Experimental data were reviewed which demonstrated that the neonatal injection effects of certain biologically active drugs (ACTH(4-10) fragment and its analogue Semax, piracetam, caffeine, levetiracetam, busperone, etc.) could be detected in adult animals as changes in physiological and behavioral reactions and in several morphological traits as well. Audiogenic seizures proneness, anxiety-fear and exploration behavior as well as pain sensitivity were analyzed. The remote effects discovered were either similar in direction to those applied to an adult organism, or opposite to it. Pharmacological treatments of such type presumably interfere the CNS development during early postnatal ontogeny and change the normal pattern ofbrain development. These modulatory influences could be due to changes in neurotransmitter system development and are presumably capable to induce CNS morphological deviations (numbers of neurons, adult neurogenesis).
pepmg summarizes the peer-reviewed literature and links to every source — it sells nothing, ships nothing, and gives no medical, dosing, or human-use guidance. Don't just trust this summary: follow the citation to its source and read it yourself. Research use only.