Study summary · research use only
The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This rat study examined the effects of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on apomorphine-induced hypothermia. Both peptides were reported to enhance hypothermia induced by intraperitoneal apomorphine (2 mg/kg), with P-DSIP's action appearing and diminishing more quickly than DSIP's. The lowest dose of both peptides producing this action was 10 ng, with an inverted bell-shaped dose-response relationship and a maximal-response dose of 1 microgram. Pretreatment with anti-DSIP abolished the enhancing action of DSIP but not P-DSIP, and haloperidol antagonized the action of both peptides. The authors suggest DSIP and P-DSIP have a close relation to the dopaminergic system in thermoregulatory mechanisms.
Abstract
Delta sleep-inducing peptide (DSIP) and P-DSIP, phosphorylated analogue, were found to have enhancing effects on hypothermia induced by i.p. injection of apomorphine (2 mg/kg), a dopamine agonist. Further, the action of P-DSIP appeared and diminished more quickly than that of DSIP. A minimal effective dose of these peptides was 10 ng and the dose-response relationship exhibited an inverted bell-shape with a maximal effective dose of 1 microgram. By the pretreatment of anti-DSIP the enhancing effect of DSIP but not P-DSIP, was totally abolished and the action of both peptides was antagonized by haloperidol. These findings suggest that DSIP and P-DSIP have a close relation to the dopaminergic system on the thermoregulatory mechanisms.
pepmg summarizes the peer-reviewed literature and links to every source — it sells nothing, ships nothing, and gives no medical, dosing, or human-use guidance. Don't just trust this summary: follow the citation to its source and read it yourself. Research use only.