Study summary · research use only
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined offspring of rats with experimental hyperhomocysteinemia induced by dietary methionine loading during pregnancy, testing the tripeptide pinealon (Glu-Asp-Arg) under these conditions. The abstract reports that pinealon administration to the pregnant methionine-loaded rats was associated with improved offspring spatial orientation and learning ability, decreased reactive oxygen species accumulation, and fewer necrotic cells among cerebellum neurons isolated from offspring exposed to prenatal hyperhomocysteinemia. The authors state these findings support neuroprotective properties of pinealon previously observed in vitro.
Abstract
The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied. Using pinealon (Glu-Asp-Arg) under these conditions was found to result in the offspring cognitive function being improved significantly and their cerebellum neurons becoming more resistant to oxidative stress. This may be proved by the fact that the administration of pinealon to pregnant rats loaded with methionine improved their offspring spatial orientation and learning ability and decreased both reactive oxygen species accumulation and the number of necrotic cells in the population of the neurons isolated from the cerebellum of the offspring developed under the prenatal hyperhomocysteinemia. Our experiments allowed confirming the neuroprotective properties of pinealon, which is in agreement with the previous data obtained by us in vitro.
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