Study summary · research use only
Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This laboratory study (species not specified) examined effects of the synthetic tripeptide pinealon (Glu-Asp-Arg) in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells under oxidative stress. The abstract reports that pinealon produced a dose-dependent restriction of reactive oxygen species (ROS) accumulation induced by receptor-dependent or -independent oxidative stress, and decreased necrotic cell death as measured by the propidium iodide test. This effect was accompanied by a delayed time course of ERK 1/2 activation and modification of the cell cycle. Because restriction of ROS accumulation and cell mortality reached a plateau at lower concentrations while cell cycle changes continued at higher concentrations, the authors concluded pinealon may interact directly with the cell genome.
Abstract
The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes. At the same time, pinealon decreases necrotic cell death measured by the propidium iodide test. The protective effect of pinealon is accompanied with a delayed time course of ERK 1/2 activation and modification of the cell cycle. Because restriction of ROS accumulation and cell mortality is saturated at lower concentrations, whereas cell cycle modulation continues at higher concentrations of pinealon, one can conclude that besides its known antioxidant activity, pinealon is able to interact directly with the cell genome.
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