Study summary · research use only
[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study in old rats compared the effects of Pinealon and Cortexin on behavior and caspase-3 activity in the brain using a carotid artery occlusion model. The abstract reports that introducing these short peptides was associated with a higher survival rate in animals with modeled carotid artery occlusion. Rats given Pinealon before occlusion showed increased behavioral sleep and reduced position-finding behavior, motivational behavior, and motor performance, while rats given Cortexin before occlusion showed increased behavioral sleep time. Pinealon administration was associated with a moderate rise in caspase-3 activity in both false-operated animals and those with occlusion.
Abstract
The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced. The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time. At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.
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