Study summary · research use only
Oral glutathione increases tissue glutathione in vivo
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this mouse study, the authors examined whether oral glutathione (GSH) increases tissue glutathione. Mice were given an oral dose of GSH (100 mg/kg), and concentrations were measured at 30, 45, and 60 min in blood plasma and after 1 h in liver, kidney, heart, lung, brain, small intestine, and skin. In control mice, plasma GSH increased from 30 microM to 75 microM within 30 min. Under these GSH-sufficient conditions, no increases over control occurred in most tissues except lung. Mice pretreated for 5 days with the synthesis inhibitor L-buthionine-S,R-sulfoximine (80 mumol/day) had decreased tissue GSH; oral GSH in these depleted animals significantly increased GSH in kidney, heart, lung, brain, small intestine, and skin but not liver. The authors report oral GSH can increase tissue GSH following depletion.
Abstract
Mice were given an oral dose of glutathione (GSH) (100 mg/kg) and concentrations of GSH were measured at 30, 45 and 60 min in blood plasma and after 1 h in liver, kidney, heart, lung, brain, small intestine and skin. In control mice, GSH concentrations in plasma increased from 30 microM to 75 microM within 30 min of oral GSH administration, consistent with a rapid flux of GSH from the intestinal lumen to plasma. Under these GSH-sufficient conditions, no increases over control values were obtained in GSH concentrations in most tissues except lung over the same time course. Mice pretreated for 5 days with the GSH synthesis inhibitor, L-buthionine-S,R-sulfoximine (BSO, 80 mumol/day) had substantially decreased tissue concentrations of GSH. Oral administration of GSH to these GSH-deficient animals gave statistically significant increases in GSH concentrations in kidney, heart, lung, brain, small intestine and skin but not in the liver. Administration of the equivalent amount of the constituent amino acids, glutamate, cysteine, and glycine, resulted in little change in GSH concentrations in all tissues in GSH-deficient animals. Thus, the results show that oral GSH can increase GSH concentrations in several tissues following GSH depletion, such as can occur in toxicological and pathological conditions in which GSH homeostasis is compromised.
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