Study summary · research use only
Anti-aging peptide bioregulators induce reactivation of chromatin
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of cultivated lymphocytes from old people (aged 75-88 years), the authors examined synthetic peptide bioregulators Epitalon, Livagen, and Vilon on structural and facultative heterochromatin. They report that all three were associated with activation of processes attributed to ribosomal-gene reactivation via decondensation of nucleolus organizer regions, deheterochromatinization of total heterochromatin, and release of genes described as repressed by condensation of euchromatic regions. Epitalon and Livagen were associated with decondensation of pericentromeric structural heterochromatin of chromosomes 1 and 9, whereas Vilon was not. The authors interpret the peptides as causing chromatin activation in lymphocytes of old individuals.
Abstract
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people. The data obtained indicate that epitalon, livagen and vilon: 1) activate synthetic processes, caused by reactivation of ribosomal genes as a result of deheterochromatinization (decondensation) of nucleolus organizer regions; 2) induce unrolling (deheterochromatinization) of total heterochromatin; 3) release genes repressed by heterochromatinization (condensation) of euchromatic regions forming facultative heterochromatin; 4) epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9. However, vilon does not induce deheterochromatinization of pericentromeric structural heterochromatin. These results indicate that peptide bioregulators Epitalon, Livagen and Vilon cause activation (deheterochromatinization) of chromatin in lymphocytes of old individuals.
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