Study summary · research use only
[Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the authors measured the circumhoralian rhythm of protein synthesis in monolayer cultures of hepatocytes from rats aged 1 to 24 months (45 to 480 g). They report that the peptide livagen (Lys-Glu-Asp-Ala) increased protein synthesis in hepatocytes across ages, with the largest effect in cells of old animals, and increased the amplitude of protein-synthesis fluctuations in old rats. The peptide epitalon (Ala-Glu-Asp-Gly) did not change protein-synthesis intensity in the cultured hepatocytes.
Abstract
The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively. The peptide lyvagen (Lys-Glu-Asp-Ala) obtained by directed chemical synthesis on the basis of amino acid analysis of the liver polypeptide preparations increased the level of protein synthesis in the hepatocytes from rats of different ages; the highest effect was observed in the cells of old animals. In old rats, lyvagen increased the amplitude of protein synthesis fluctuations. The peptide epitalon (Ala-Glu-Asp-Gly) constructed on the basis of analysis of the epiphysis peptides did not change the intensity of protein synthesis in the cultured hepatocytes.
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