Study summary · research use only
Peptide Epitalon activates chromatin at the old age
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of cultured lymphocytes from people aged 76-80 years, the authors examined the synthetic peptide Epitalon's effect on ribosomal gene activity, heterochromatin denaturation parameters, structural C-heterochromatin polymorphism, and facultative heterochromatin variability. They report that Epitalon was associated with activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes described as repressed by age-related chromatin condensation. The authors interpret the findings as showing Epitalon modifying heterochromatin and heterochromatinized chromosome regions in cells of older people.
Abstract
OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years. The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions. Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.
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