Study summary · research use only
Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study, aged Wistar rats received oral Vilon (Lys-Glu) or Epithalon (Ala-Glu-Asp-Gly) for 1 month. The authors reported that both peptides were associated with a significant increase in activity of the membrane enzymes maltase and alkaline phosphatase in the epithelial layer of the small intestine. Vilon was also associated with increased activity of cytosolic glycyl-L-leucine dipeptidase in the stromal and seromuscular layers compared to untreated control rats. The authors interpreted these findings as suggesting improved trophic and barrier function of the small intestine in aged rats, and as supporting the existence of a subepithelial enzymatic barrier in addition to the epithelial one.
Abstract
Per os administration of Vilon (Lys-Glu) or Epithalon (Ala-Glu-Asp-Gly) to aged Wistar rats for 1 month significantly increased activity of membrane enzymes maltase and alkaline phosphatase in epithelial layer of the small intestine. In addition, Vilon significantly increased activity of cytosolic glycyl-L-leucine dipeptidase in the stromal and seromuscular layers of the small intestine in comparison with the control rats not treated with this agent. These findings suggest improvement of trophic and barrier functions of the small intestine and corroborate the hypothesis on the existence of not only epithelial, but also subepithelial enzymatic barrier supporting the enzyme system in the small intestine, especially in aged animals.
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