Study summary · research use only
Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study, female transgenic FVB/N mice carrying the HER-2/neu breast cancer gene received epithalon (Ala-Glu-Asp-Gly) subcutaneously at 1 mg, 5 times a week, from the 2nd month of life until death. The authors reported that epithalon lengthened average and maximum lifetimes by 13.5% and 13.9%, and lengthened average lifetime of tumor-free animals by 34.2%. Lung metastases decreased by 1.6 times and multiple tumors by 2 times; mice without breast tumors increased 3.7-fold, while mice with 6 or more tumors decreased by 3 times. Lifetime of mice with tumors increased by 1.4 times. The authors linked these findings to suppression of HER-2/neu expression.
Abstract
Female transgenic FVB/N mice carrying the breast cancer gene HER-2/neu received epithalon (Ala-Glu-Asp-Gly) in a dose of 1 mg subcutaneously 5 times a week to from the 2nd month of life to death. Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. The peptide prolonged the average lifetime of animals without neoplasms (by 34.2%, p<0.05). Epithalon decelerated the development of age-related disturbances in reproductive activity and suppressed the formation of neoplasms. The peptide decreased the incidence of breast adenocarcinomas, lungs metastases (by 1.6 times, p<0.05), and multiple tumors (by 2 times). Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). These results indicate that Epithalon possesses geroprotective activity and inhibits breast carcinogenesis in transgenic mice, which is probably related to suppression of HER-2/neu expression.
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