Study summary · research use only
Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This mouse study used DNA-microarray technology to examine expression of 15,247 heart cDNA clones in mice treated with Vilon and Epithalon. The authors identified 300 clones (1.94% of the total) with expression changed by more than 2 times. Vilon altered expression of 36 clones and Epithalon altered 98; combined treatment altered 144. Vilon alone or combined with Epithalon activated 157 clones (up to 6.13 times) and inhibited 23 (up to 2.79 times). Epithalon alone or combined with Vilon activated 194 clones (up to 6.61 times) and inhibited 48 (up to 2.71 times). The authors describe these as specific gene-expression associations for each peptide.
Abstract
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology. We revealed 300 clones (1.94% of the total count), whose expression changed more than by 2 times. Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones. Combined treatment with Vilon and Epithalon changed expression of 144 clones. Vilon alone or in combination with Epithalon activated expression of 157 clones (maximally by 6.13 times) and inhibited expression of 23 clones (maximally by 2.79 times). Epithalon alone or in combination with Vilon activated expression of 194 clones (maximally by 6.61 times) and inhibited expression of 48 clones (maximally by 2.71 times). Our results demonstrate the specific effects of Epithalon and Vilon on gene expression.
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